as of September, 2021:
| County | Employment | Unemployment | Unemployment Rate | Labor Force |
|---|---|---|---|---|
| Adams | 267,835 | 15,543 | 5.5 | 283,378 |
| Alamosa | 8,087 | 410 | 4.8 | 8,497 |
| Arapahoe | 359,680 | 19,470 | 5.1 | 379,150 |
| Archuleta | 7,487 | 290 | 3.7 | 7,777 |
| Baca | 2,237 | 41 | 1.8 | 2,278 |
| Bent | 1,839 | 107 | 5.5 | 1,946 |
| Boulder | 192,647 | 7,226 | 3.6 | 199,873 |
| Broomfield | 39,827 | 1,586 | 3.8 | 41,413 |
| Chaffee | 10,204 | 338 | 3.2 | 10,542 |
| Cheyenne | 1,090 | 23 | 2.1 | 1,113 |
| Clear Creek | 6,000 | 315 | 5.0 | 6,315 |
| Conejos | 3,926 | 168 | 4.1 | 4,094 |
| Costilla | 1,720 | 92 | 5.1 | 1,812 |
| Crowley | 1,505 | 68 | 4.3 | 1,573 |
| Custer | 2,186 | 79 | 3.5 | 2,265 |
| Delta | 14,180 | 604 | 4.1 | 14,784 |
| Denver | 413,788 | 22,638 | 5.2 | 436,426 |
| Dolores | 1,134 | 43 | 3.7 | 1,177 |
| Douglas | 194,966 | 7,014 | 3.5 | 201,980 |
| Eagle | 31,495 | 1,367 | 4.2 | 32,862 |
| El Paso | 343,348 | 17,311 | 4.8 | 360,659 |
| Elbert | 15,126 | 489 | 3.1 | 15,615 |
| Fremont | 15,767 | 960 | 5.7 | 16,727 |
| Garfield | 30,091 | 1,266 | 4.0 | 31,357 |
| Gilpin | 3,806 | 201 | 5.0 | 4,007 |
| Grand | 8,308 | 328 | 3.8 | 8,636 |
| Gunnison | 11,270 | 334 | 2.9 | 11,604 |
| Hinsdale | 458 | 12 | 2.6 | 470 |
| Huerfano | 2,645 | 184 | 6.5 | 2,829 |
| Jackson | 958 | 22 | 2.2 | 980 |
| Jefferson | 330,285 | 14,737 | 4.3 | 345,022 |
| Kiowa | 1,000 | 19 | 1.9 | 1,019 |
| Kit Carson | 4,178 | 118 | 2.7 | 4,296 |
| La Plata | 30,595 | 1,292 | 4.1 | 31,887 |
| Lake | 4,316 | 187 | 4.2 | 4,503 |
| Larimer | 199,624 | 8,073 | 3.9 | 207,697 |
| Las Animas | 6,397 | 396 | 5.8 | 6,793 |
| Lincoln | 2,350 | 81 | 3.3 | 2,431 |
| Logan | 10,872 | 407 | 3.6 | 11,279 |
| Mesa | 73,463 | 3,720 | 4.8 | 77,183 |
| Mineral | 407 | 16 | 3.8 | 423 |
| Moffat | 7,293 | 277 | 3.7 | 7,570 |
| Montezuma | 12,572 | 585 | 4.4 | 13,157 |
| Montrose | 21,060 | 926 | 4.2 | 21,986 |
| Morgan | 15,441 | 715 | 4.4 | 16,156 |
| Otero | 8,050 | 453 | 5.3 | 8,503 |
| Ouray | 2,644 | 102 | 3.7 | 2,746 |
| Park | 11,275 | 383 | 3.3 | 11,658 |
| Phillips | 2,321 | 60 | 2.5 | 2,381 |
| Pitkin | 10,345 | 456 | 4.2 | 10,801 |
| Prowers | 5,982 | 237 | 3.8 | 6,219 |
| Pueblo | 72,962 | 5,516 | 7.0 | 78,478 |
| Rio Blanco | 2,932 | 130 | 4.2 | 3,062 |
| Rio Grande | 5,318 | 292 | 5.2 | 5,610 |
| Routt | 15,091 | 568 | 3.6 | 15,659 |
| Saguache | 3,168 | 170 | 5.1 | 3,338 |
| San Juan | 557 | 13 | 2.3 | 570 |
| San Miguel | 4,506 | 202 | 4.3 | 4,708 |
| Sedgwick | 1,150 | 38 | 3.2 | 1,188 |
| Summit | 19,285 | 783 | 3.9 | 20,068 |
| Teller | 13,050 | 558 | 4.1 | 13,608 |
| Washington | 2,972 | 73 | 2.4 | 3,045 |
| Weld | 162,163 | 8,261 | 4.8 | 170,424 |
| Yuma | 5,399 | 143 | 2.6 | 5,542 |